Manual Therapy, Posturology & Rehabilitation Journal
Manual Therapy, Posturology & Rehabilitation Journal
Research Article

Photobiomodulation with Led 627nm associated to resveratron in cutaneous injuries of rats: a double-blind controlled clinical study.

Patricia Pacheco Tyski Suckow, Ana Carolina Dorigoni Bini, Paulo Renato de Oliveira, Larissa Sakis Bernardi, Danillo Barbosa, Ivo Ilvan Kerppers, Alice Pansera, Gabriela de França Cury, Jaqueline Emiliano, Andressa Panegalli Hosni, Andressa Leticia Miri

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Introduction: Drugs formulated as Resveratrol, associated with LED 627nm photobiomodulation, can increase the efficacy of active release, increased local circulation, cell proliferation and collagen synthesis, accelerating the healing process. Objective: To analyze the effects of 627nm LED photobiomodulation associated with Resveratrol on the tissue repair of induced wounds in Wistar rats. Methodology: We used 18 animals corresponding to the control groups, group LED 627nm with association to Resveratrol cream (GLed + Resv) 3 and 7 days. Results: Treatment with the use of LED associated with Resveratrol cream provided an efficient healing. In the statistical test, the significance level was observed between the groups of P <0.0156. In the multiple comparison between the pairs the Tukey’s test showed significance between the groups CG vs GLed627nm + Resv 7Day. Conclusion: The GLed + Resv group showed efficient inflammatory phase of healing, promoting a greater activation of fibroblasts and remodeling of the collagen fiber when compared to the control group.


Punch; Healing; Photobiomodulation; Resveratrol.


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